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The occurrence of a common source hepatitis A epidemic among the residents of a New England state mental institution where hepatitis B is hyperendemic provided an opportunity to observe concurrent infections with both agents. Nine HBsAg-positive individuals developed hepatitis A infections documented by hepatitis A antibody seroconversion in eight. The incidence of hepatitis A infections in susceptible HBsAg-positive persons (67%) did not differ from that in HBsAg-negative individuals (63%). The icteric to anicteric infection ratio in the HBsAG-positives (1:1.7) was similar to that in the negatives (1:2.1), and the clinical course in the antigen positives did not differ significantly from that of the antigen negatives. In addition to confirming previous reports that the viruses of hepatitis A and B are immunologically distinct, these results document that infection with either is independent of the other, and that the morbidity from simultaneous infection is no greater than that caused by either alone.
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
December 2019,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
July 1983,
Gastroenterology,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
January 1984,
Terapevticheskii arkhiv,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
August 1982,
Digestive diseases and sciences,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
March 1979,
The Journal of infectious diseases,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
January 1986,
Sovetskaia meditsina,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
January 1984,
Vojnosanitetski pregled,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
January 1994,
BMJ (Clinical research ed.),
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
December 1983,
Liver,
S H Hindman, and
J E Maynard, and
D W Bradley, and
K R Berquist, and
A E Denes
April 1997,
Communicable disease report. CDR review,
