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The level of adenosine 3':5'-cyclic monophosphate (cAMP) and the activity of adenyl cyclase were studied in the pancreas under normal conditions and during acute hemorrhagic pancreatitis induced by intraductal injection of fresh trypsin-bile-blood mixture. In addition, the adenyl cyclase was localized histochemically in the pancreas. Basal cAMP concentration and adenyl cyclase activity were 0.88 +/- 0.11 pmoles/mg wet tissue and 3.39 +/- 0.21 pmoles/mg protein/min, respectively. The acute pancreatitis drastically reduced the adenyl cyclase activity at 15 minutes to 1.66 +/- 0.54 pmoles/mg protein/min, and totally suppressed adenyl cyclase activity at 30 minutes after the onset of pancreatitis without affecting cAMP levels. The presence of sodium fluoride in the incubation medium prolonged the enzyme activity up to 45 minutes. The progressive disappearance of adenyl cyclase activity presumably resulted from the destruction of cellular integrity caused by autodigestion by the active proteolytic enzymes released during pancreatitis.
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
October 1976,
Rhode Island medical journal,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
April 1977,
Journal of neurosurgery,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
January 1974,
Advances in cardiology,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
November 1976,
The Journal of surgical research,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
January 1970,
Developmental psychobiology,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
December 1971,
The Journal of laboratory and clinical medicine,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
January 1973,
Advances in experimental medicine and biology,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
September 1973,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
March 1971,
Journal of molecular and cellular cardiology,
B F Gabrys-Pomykala, and
O Holian, and
M MacKenzie, and
L M Nyhus, and
C T Bombeck
March 1971,
Circulation,
