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State of oxygen consumption in gastric mucosal membrane evaluated by means of pO2 measurement as well as metabolism of cyclic nucleotides were studied in patients with ulcerous disease. Hypoxia of periulcerous area and alterations in functional activity of the cyclase systems were detected. Reciprocal alterations in the cyclases activity, as a result of which the ratio of cyclic nucleotides was changed under dissimilar conditions of oxygen consumption in gastric mucosal membrane, were considered as essential adaptive reaction related to maintenance of proliferation under conditions of oxygen and energy rich substances deficiency.
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