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1. In the isolated perfused rat gut oestrone was not taken up from the perfusate but was rapidly taken up from the gut lumen when administered in dimethyl sulphoxide or in 10% acetone in water. 2. Uptake from corn oil was much slower and the rate was concentration-dependent. 3. When given in dimethyl sulphoxide or in aqueous acetone, the residual oestrone in the gut lumen was largely unchanged, with only about 10% being present as the glucuronide. Of the oestrone in the gut perfusate, some 40% was glucuronidated. 4. No evidence was obtained for any reduction or hydroxylation, or for any sulphation, during uptake of oestrone by the gut. 5. No secretion of oestrone or its metabolites into lymph could be detected.
A B Roy, and
C G Curtis, and
H Hughes
January 1977,
Biochemical Society transactions,
A B Roy, and
C G Curtis, and
H Hughes
January 1976,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
A B Roy, and
C G Curtis, and
H Hughes
June 2004,
Environmental toxicology and pharmacology,
A B Roy, and
C G Curtis, and
H Hughes
January 1970,
Canadian journal of physiology and pharmacology,
A B Roy, and
C G Curtis, and
H Hughes
December 1963,
British journal of pharmacology and chemotherapy,
A B Roy, and
C G Curtis, and
H Hughes
March 1974,
British journal of pharmacology,
A B Roy, and
C G Curtis, and
H Hughes
January 1970,
Naunyn-Schmiedebergs Archiv fur Pharmakologie,
A B Roy, and
C G Curtis, and
H Hughes
August 1980,
Proceedings of the National Academy of Sciences of the United States of America,
A B Roy, and
C G Curtis, and
H Hughes
January 1995,
Naunyn-Schmiedeberg's archives of pharmacology,
A B Roy, and
C G Curtis, and
H Hughes
April 1969,
Biochemical pharmacology,
