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Alzheimer's disease, which is characterized by amyloid plaques and neurofibrillary tangles, may be attributed to the abnormal expression of gene(s) located on human chromosome 21. Genetic linkage studies have narrowed the region of candidate genes to 21q11.2-21q22 of the long arm of this chromosome. Several single copy sequences within this region, including the amyloid precursor protein (APP), have been mapped to mouse chromosome 16. Reliable strategies exist for breeding Trisomy 16 mice. However, the consequences of developmental overexpression of genes on chromosome 16 have not been previously investigated, because of the lethal effects of this aneuploidy during gestation. In the present report, we employ neural transplantation to study long-term survival and pathogenesis in Trisomy 16 central nervous system tissues. Immunocytochemical staining with antiserum raised against the synthetic APP, beta-A4 and alpha 1-antichymotrypsin revealed numerous densely stained cells within hippocampal grafts of Trisomy 16 mice. Similarly, a population of grafted cells were positively stained following incubation with an antiserum raised against components of the pathological neurofibrillary tangle and with the monoclonal antibodies Tau 6.423 and ubiquitin.
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
August 1994,
Tissue & cell,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
May 1993,
Brain research,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
August 1991,
Trends in neurosciences,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
January 1994,
Critical reviews in neurobiology,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
September 1988,
Trends in neurosciences,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
August 2003,
The Journal of comparative neurology,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
February 1992,
Proceedings of the National Academy of Sciences of the United States of America,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
April 2004,
Magnetic resonance in medicine,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
July 2003,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
S J Richards, and
J J Waters, and
K Beyreuther, and
C L Masters, and
C M Wischik, and
D R Sparkman, and
C L White, and
C R Abraham, and
S B Dunnett
April 2005,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
