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To study the role played by normal levels of plasma prolactin (PRL) in the secretion of testosterone (T) in the testes, we induced hypoprolactinemia with a daily dose of 5 mg bromocriptine administered orally in five normal men 20 to 35 years of age for 8 weeks. The basal PRL, T, luteinizing hormone, follicle-stimulating hormone, and maximum responses of plasma T to human chorionic gonadotropin (hCG) stimulation were measured every 2 weeks. Basal levels of plasma T were reduced in the 1st 2-week-long period of hypoprolactinemia. In the 4-week-long period of hypoprolactinemia, the maximal response of plasma T to hCG stimulation was significantly reduced. The findings suggest that normal levels of plasma PRL may play an important role in the secretion of T in the human testes in vivo.
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A Nakano, and
K Morikawa, and
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A Taniguchi, and
T Usui
July 1975,
The Journal of clinical endocrinology and metabolism,
F Oseko, and
A Nakano, and
K Morikawa, and
J Endo, and
A Taniguchi, and
T Usui
May 2005,
The Journal of clinical endocrinology and metabolism,
F Oseko, and
A Nakano, and
K Morikawa, and
J Endo, and
A Taniguchi, and
T Usui
January 1980,
The Journal of clinical endocrinology and metabolism,
F Oseko, and
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J Endo, and
A Taniguchi, and
T Usui
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F Oseko, and
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F Oseko, and
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A Taniguchi, and
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F Oseko, and
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T Usui
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The Journal of clinical endocrinology and metabolism,
F Oseko, and
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A Taniguchi, and
T Usui
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F Oseko, and
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