Biomaterial Database

Lateral parabrachial nucleus mediates shortening of expiration and increase of inspiratory drive during hypercapnia. 2009

Gang Song, and Chi-Sang Poon

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We have previously shown that unilateral or bilateral lesions of the lateral parabrachial nucleus (LPBN) in anesthetized, vagotomized rats markedly and selectively attenuate the shortening of expiratory duration (T(E)) during hypoxia without appreciably affecting all other hypoxic response components. Here, we report that unilateral LPBN lesion by kainic acid in the same group of animals not only abolished normal T(E)-shortening during central chemoreceptors activation by hyperoxic hypercapnia, but led to paradoxical T(E)-prolongation and corresponding decrease of respiratory frequency. Furthermore, LPBN lesion significantly attenuated the increase in phrenic activity during hyperoxic hypercapnia, without appreciably affecting the corresponding shortening of inspiratory duration (T(I)). These findings provide the first evidence indicating that central chemoafferent inputs are organized in parallel and segregated pathways that separately modulate inspiratory drive, T(I), and T(E) in conjunction with similar parallel and segregated central processing of peripheral chemoafferent inputs reported previously [Young, D.L., Eldridge, F.L., Poon, C.S., 2003. Integration-differentiation and gating of carotid afferent traffic that shapes the respiratory pattern. J. Appl. Physiol. 94, 1213-1229].

UI	MeSH Term	Description	Entries
D007839	Functional Laterality	Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.	Ambidexterity,Behavioral Laterality,Handedness,Laterality of Motor Control,Mirror Writing,Laterality, Behavioral,Laterality, Functional,Mirror Writings,Motor Control Laterality,Writing, Mirror,Writings, Mirror
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010791	Phrenic Nerve	The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.	Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D011149	Pons	The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.	Pons Varolii,Ponte,Pons Varolius,Pontes,Varolii, Pons,Varolius, Pons
D012122	Ventilators, Mechanical	Mechanical devices used to produce or assist pulmonary ventilation.	Mechanical Ventilator,Mechanical Ventilators,Respirators,Ventilators, Pulmonary,Pulmonary Ventilator,Pulmonary Ventilators,Ventilator, Pulmonary,Ventilators,Respirator,Ventilator,Ventilator, Mechanical
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006935	Hypercapnia	A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor