BIOMAT Database Logo BIOMAT Database Logo

Fungistatic effects of optical brightener 220 against Trichophyton tonsurans, Aspergillus fumigatus and Candida albicans. 2009

Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Department of Mycology, Pasteur Institute of Iran, Tehran, Iran. gsadeghi@pasteur.ac.ir

BACKGROUND Dermatophytes are one of the main causes of dermal infections. Moreover, there are some opportunistic fungi such as Aspergillus fumigatus (mycelial form) and Candida albicans (yeasty form) that in immunosuppressed patients can cause cutaneous disease. OBJECTIVE The possible effect of optical brightener 220 (OB-220) on the growth of fungi has been evaluated in this study. METHODS Isolates were grown on agar plates containing OB-220 in concentration between 0.06 and 11.68 mg ml(-1). MICs of OB-220, ketoconazole and fluconazole were obtained by the agar dilution method. Hyphae and yeasts grown with OB-220 were compared with controls by fluorescence and transmission electron microscopy. The cell cytotoxicity of OB-220 was also assessed. RESULTS The MIC(90) of OB-220 was obtained: 1.17-1.46 mg ml(-1) for A. fumigatus, 0.58-1.17 mg ml(-1) for C. albicans and 0.29 mg ml(-1) for Trichophyton tonsurans. Electron microscopy revealed a thickening and blurred contours of the cell wall by OB-220. OB-220 in concentrations up to 11.68 mg ml(-1) posed no mammalian cell toxicity. CONCLUSIONS OB-220 suppresses the growth of fungi by interfering with the formation of normal chitin.

UI MeSH Term Description Entries
D007654 Ketoconazole Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. Nizoral,R-41400,R41,400,R41400,R 41400
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D002176 Candida albicans A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis). Candida albicans var. stellatoidea,Candida stellatoidea,Dematium albicans,Monilia albicans,Myceloblastanon albicans,Mycotorula albicans,Parasaccharomyces albicans,Procandida albicans,Procandida stellatoidea,Saccharomyces albicans,Syringospora albicans
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D001232 Aspergillus fumigatus A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals. Aspergillus fumigates,Neosartorya fumigata,Sartorya fumigata
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor

Related Publications

Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans.
January 2016, Drug design, development and therapy,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Antifungal mechanism of FK463 against Candida albicans and Aspergillus fumigatus.
February 2002, The Journal of antibiotics,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans.
June 2011, Blood,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Expression, purification and in vitro antifungal activity of acidic mammalian chitinase against Candida albicans, Aspergillus fumigatus and Trichophyton rubrum strains.
January 2009, Clinical and experimental dermatology,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.
November 2018, Scientific reports,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis.
February 2018, Fungal genetics and biology : FG & B,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
On the immunochemical and biochemical studies of fungi. XI. Cross reaction of the polysaccharides of Aspergillus fumigatus, Candida albicans, Saccharomyces cerevisiae and Trichophyton rubrum against Candida albicans and Saccharomyces cerevisiae antisera.
December 1967, Japanese journal of microbiology,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus.
June 2006, Nature reviews. Microbiology,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Intrinsic in vitro susceptibility of primary clinical isolates of Aspergillus fumigatus, Aspergillus terreus, Aspergillus nidulans, Candida albicans and Candida lusitaniae against amphotericin B.
March 2006, Mycoses,
Golnar Sadeghi, and Ali Asghar Khaksar, and Shahindokht Bassiri Jahromi, and Aref Amirkhani, and Ali Eslamifar, and Soheila Ajdary, and Farzad Katiraee, and Jaleh Taeb, and Farnoosh Asghari Paskiabi, and Mohammad Sayyah
Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.
March 2002, Chest,
Copied contents to your clipboard!