Microbial transformation of alantolactone by Mucor polymorphosporus. 2008

Xiu-Lan Xin, and Xiao-Chi Ma, and Ke-Xin Liu, and Jian Han, and Bao-Rong Wang, and De-An Guo
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Two new transformed sesquiterpenes of alantolactone by Mucor polymorphosporus were obtained. They were characterized as 3beta-hydroxy-11betaH-eudesm-5-en-8beta,12-olide (2) and 3beta,11alpha-dihydroxy-eudesm-5-en-8beta,12-olide (3), on the basis of spectral methods including 2D NMR. And product 3 was an unusual hydroxylation derivative of alantolactone at C-11.

UI MeSH Term Description Entries
D007783 Lactones Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES. Lactone
D009089 Mucor A genus of zygomycetous fungi of the family Mucoraceae, order Mucorales. It is primarily saprophytic, but may cause MUCORMYCOSIS in man from spores germinating in the lungs. Mucors
D012717 Sesquiterpenes Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24. Farnesanes,Farnesene,Farnesenes,Sesquiterpene,Sesquiterpene Derivatives,Sesquiterpenoid,Sesquiterpenoids,Derivatives, Sesquiterpene
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D045787 Sesquiterpenes, Eudesmane SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS. Eudesmane Derivatives,Eudesmanes,Furanoeremophilane Derivatives,Furanoeremophilanes,Furanoeudesmane Derivatives,Furanoeudesmanes,Derivatives, Eudesmane,Derivatives, Furanoeremophilane,Derivatives, Furanoeudesmane,Eudesmane Sesquiterpenes

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