-transparent.png){kind=logo}
V-H4, a mitomycin C (MMC)-sensitive Chinese hamster cell mutant, is phenotypically very similar to Fanconi anemia (FA) cells. Genetic complementation analysis shows that V-H4 belongs to the same complementation group as FA group A cells. Proliferating hybrid cell lines obtained after fusion of V-H4 with normal or FA group B cells show an increased resistance to MMC. Absence of complementation was noted in V-H4 x FA group A hybrid cell lines. This was shown not to be due to the absence of a specific human chromosome. The V-H4 mutant represents the first rodent mutant that is genotypically similar to FA complementation group A cells.
Related Publications
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
March 1996,
Mutagenesis,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
March 1994,
Mutation research,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
September 2004,
Biology of the cell,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
August 1995,
Cancer research,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
May 1991,
Mutagenesis,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
June 1999,
Biochemical and biophysical research communications,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
March 1998,
Molecular genetics and metabolism,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
December 2001,
Experimental hematology,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
January 1997,
Somatic cell and molecular genetics,
F Arwert, and
M A Rooimans, and
A Westerveld, and
J W Simons, and
M Z Zdzienicka
January 2021,
Molecular biology reports,
