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Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides. 2008
Je Won Park, and
Hong-Se Oh, and
Won Seok Jung, and
Sung Ryeol Park, and
Ah Reum Han, and
Yeon-Hee Ban, and
Eun Ji Kim, and
Han-Young Kang, and
Yeo Joon Yoon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.
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