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Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factor beta (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factor alpha (0.1-10 ng/ml) and interferon gamma (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1 beta, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor beta has a potent effect on endothelin release from endothelial cells of different organs.
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P Molinatti, and
M Ghatei, and
S R Bloom
January 1995,
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S R Bloom
March 1996,
Experientia,
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August 1997,
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S M Kanse, and
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A Rees, and
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M Porta, and
P Molinatti, and
M Ghatei, and
S R Bloom
June 1991,
Journal of molecular and cellular cardiology,
S M Kanse, and
K Takahashi, and
H C Lam, and
A Rees, and
J B Warren, and
M Porta, and
P Molinatti, and
M Ghatei, and
S R Bloom
February 1995,
The Journal of infectious diseases,
S M Kanse, and
K Takahashi, and
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A Rees, and
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P Molinatti, and
M Ghatei, and
S R Bloom
April 1990,
Endocrinology,
S M Kanse, and
K Takahashi, and
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A Rees, and
J B Warren, and
M Porta, and
P Molinatti, and
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S R Bloom
January 1998,
Journal of cardiovascular pharmacology,
S M Kanse, and
K Takahashi, and
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A Rees, and
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M Porta, and
P Molinatti, and
M Ghatei, and
S R Bloom
May 1991,
Biochemical and biophysical research communications,
S M Kanse, and
K Takahashi, and
H C Lam, and
A Rees, and
J B Warren, and
M Porta, and
P Molinatti, and
M Ghatei, and
S R Bloom
April 1993,
Recenti progressi in medicina,
S M Kanse, and
K Takahashi, and
H C Lam, and
A Rees, and
J B Warren, and
M Porta, and
P Molinatti, and
M Ghatei, and
S R Bloom
March 1995,
Hypertension (Dallas, Tex. : 1979),
