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A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity. 2009
Beatrice Mercorelli, and
Giulia Muratore, and
Elisa Sinigalia, and
Oriana Tabarrini, and
Maria Angela Biasolo, and
Violetta Cecchetti, and
Giorgio Palù, and
Arianna Loregian
Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padua, Italy.
We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.
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