-transparent.png){kind=logo}
The genotoxicity of a chelating agent, the trisodium salt of nitrilotriacetic acid (NTA), was assessed in a somatic mutation and recombination test (SMART) in Drosophila melanogaster employing the wing hair markers mwh and flr3. The experiments were performed in parallel in two different laboratories (Padua, Italy and Schwerzenbach, Switzerland). The effectively absorbed doses of NTA, which was administered by feeding to larvae, were determined by a sensitive method employing [3H]leucine which allowed individual consumption levels to be measured. The particular pattern of clone induction produced by this compound suggests that NTA is active in inducing mitotic recombination and possibly aneuploidy in somatic cells of Drosophila. This is discussed in relation to the data present in the literature regarding the genotoxicity of NTA in a variety of experimental systems.
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
January 1984,
Environmental mutagenesis,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
May 1991,
Mutation research,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
June 2017,
Journal of medicinal food,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
August 2005,
Radiation research,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
February 1988,
Mutation research,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
March 1989,
Mutagenesis,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
April 2001,
Bulletin of environmental contamination and toxicology,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
January 2006,
Drug and chemical toxicology,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
November 2009,
Mutation research,
M Zordan, and
U Graf, and
D Singer, and
C Beltrame, and
L Dalla Valle, and
M Osti, and
R Costa, and
A G Levis
May 1994,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
