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Influenza A virus causes prevalent respiratory tract infections in humans. Small interfering RNA (siRNA) and antisense oligonucleotides (asODNs) have been used previously for silencing the RNA genome of influenza virus. Here, we explored the use of partially double-stranded oligodeoxynucleotides (dsODNs) to suppress the production of influenza A virus in cell cultures and animal models. We were able to inhibit influenza A virus replication in cultured human lung cells as well as in the lungs of infected C57BL/6 mice by treatment with dsODN 3-h post-infection. In about 20% of the cases (15/77) the titer was reduced by 10- to 100-fold and in 10% up to 1,000-fold. The antiviral effects of dsODNs were dose-dependent, sequence-dependent and comparable to those of its antisense and siRNA analogues. Thus, dsODNs may be developed as an additional class of nucleic acids for the inhibition of influenza virus replication.
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
May 1990,
Proceedings of the National Academy of Sciences of the United States of America,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
August 1988,
Proceedings of the National Academy of Sciences of the United States of America,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
May 2005,
The Journal of infectious diseases,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
February 2000,
International journal of immunopharmacology,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
February 1993,
The Journal of biological chemistry,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
July 2012,
Virology journal,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
January 1991,
Antiviral research,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
March 2018,
Journal of the science of food and agriculture,
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
February 2022,
Pathogens (Basel, Switzerland),
Terry Kwok, and
Hanspeter Helfer, and
Mohammad Intakhab Alam, and
Jochen Heinrich, and
Jovan Pavlovic, and
Karin Moelling
October 1999,
Journal of virology,
