Biomaterial Database

[Long-term changes of corneal endothelial cells with radial keratotomy]. 2008

Lu Zhao, and Yan-ling Wang, and Ping Liu, and Xuan Liu

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

OBJECTIVE To investigate the long-term loss and variation of corneal endothelial cells after radial keratotomy. METHODS By the way of case-control study, 51 myopia (101 eyes) patients who underwent RK in Beijing Friendship hospital, from January 1989 to December 1996 is the RK group. 51 myopia (102 eyes) outpatients who have no other eye diseases is the control group. The volunteers are the outpatients of Department of Ophthalmology in Beijing Friendship Hospital from November 2006 to March 2007. Corneal endothelial cells are examined by Topcon SP2000 non-contact corneal endothelial microscope. To survey corneal endothelium of center, superior, inferior, temple side and nasal side, to study endothelial cell density, average areas, coefficient of cell variation in size and hexagonality. RESULTS The differences of endothelial cell density, average areas, hexagonality are no significant between the RK group and the control group with the same age stage (P > 0.05). The differences of coefficient of cell variation are significant. In the 30 year old stage, the result of center is t = 3.742, P = 0.000, the result of superior is t = 3.627, P = 0.000, the result of inferior is t = 3.180, P = 0.002, the result of nasal side is t = 2.448, P = 0.016, the result of temple side is t = 3.149, P = 0.002. In the 40 year old stage, the result of center is t = 4.446, P = 0.000, the result of superior is t = 2.444, P = 0.017, the result of inferior is t = 2.113, P = 0.038, the result of nasal side is t = 3.214, P = 0.002, the result of temple side is t = 2.680, P = 0.009. In the 50 year old stage, the result of center is t = 2.360, P = 0.024, the result of superior is t = 2.600, P = 0.013, the result of inferior is t = 2.787, P = 0.008, the result of nasal side is t = 2.144, P = 0.038, the result of temple side is t = 2.177, P = 0.036. But the differences of coefficient of cell variation have no relationship with the time of RK (P > 0.05). The differences of endothelial cell density, average areas, coefficient of cell variation in size and hexagonality are no significant among different incision group (P > 0.05). There are impalpable changes in the morphology of endothelial cells, coefficient of cell variation in size is greater than the control with the same age stage. CONCLUSIONS If proforming other eye operations to RK patients, it is necessary to evaluate the corneal endothelial cells before operations.

UI	MeSH Term	Description	Entries
D007646	Keratotomy, Radial	A procedure to surgically correct REFRACTIVE ERRORS by cutting radial slits into the CORNEA to change its refractive properties.	Radial Keratotomy,Keratotomies, Radial,Radial Keratotomies
D008297	Male		Males
D011184	Postoperative Period	The period following a surgical operation.	Period, Postoperative,Periods, Postoperative,Postoperative Periods
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D004728	Endothelium, Corneal	Single layer of large flattened cells covering the surface of the cornea.	Anterior Chamber Epithelium,Corneal Endothelium,Endothelium, Anterior Chamber,Epithelium, Anterior Chamber,Anterior Chamber Endothelium
D004847	Epithelial Cells	Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.	Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D016022	Case-Control Studies	Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time.	Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control