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Endothelium function was assessed from endothelium-dependent vasodilation and plasma endothelin-1 (ET-1) levels in 16 patients with arterial hypertyension (AH) and insulin resistance (IR) and compared with that in 22 patients with AH without IR. IR was diagnosed indirectly from the fasting glucose-to-insulin ratio in venous blood below 6. Additional studies included round-the-clock monitoring arterial pressure, reactive hyperemia test, and immunoreactive ET-1 assay. Major changes revealed in the patients with AH and IR were a smaller-than-normal diameter of the humeral artery, its decreased incremental growth, and elevated plasma ET-1 compared with the AH patients without IR. It is concluded that patients with AH and IR exhibit more pronounced dysfunction of endothelium than patients with AH without metabolic disorders.
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 1969,
Medicina interna,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 2002,
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G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
February 1973,
American heart journal,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 2010,
Klinicheskaia meditsina,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 1996,
Medicina,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
July 1970,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 1982,
Giornale italiano di cardiologia,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 2020,
Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
January 2002,
Terapevticheskii arkhiv,
G A Dzhunusbekova, and
M K Tundybaeva, and
A K Dzhusipov
March 1985,
Kardiologiia,
