In the present study, we aimed to investigate the effects of electroacupuncture treatment on lipoprotein A, apolipoprotein A and apolipoprotein B levels in obese subjects. Fifty-eight women were studied in 3 groups as follows: 1) Placebo acupuncture (n = 15; mean age = 41.47 +/- 4.61, and mean body mass index {BMI} = 33.43 +/- 3.10); 2) Electroacupuncture (EA) (n = 20; mean age = 40.55 +/- 5.30, and BMI = 35.65 +/- 3.84) and 3) Diet restriction groups (n = 23; mean age = 42.91 +/- 4.02, and BMI = 34.78 +/- 3.29). EA was performed using the ear points, Hungry, Shen Men and Stomach the body points, Hegu (LI 4), Quchi (LI 11), Tianshu (St 25), Zusanli (St 36), Neiting (St 44) and Taichong (Liv 3) for 20 days. Intragroup comparisons were made by using paired samples t-test whereas intergroup differences were investigated by the two-way variation analysis and LSD test. There was a 4.7% (p < 0.001) weight reduction in patients with electroacupuncture application, whereas patients in diet restriction had a 2.9% (p < 0.001) weight reduction. There were significant decreases in lipoprotein A (p < 0.05) and apolipoprotein B (p < 0.05) levels in the EA compared to the control group and no changes in apolipoprotein A levels was observed in EA, diet and placebo acupuncture groups. EA therapy may be a useful approach for the treatment of obesity for both losing weight and lowing the risk factors for cardiovascular disease associated with obesity, since this application may decrease the plasma lipoprotein A and apolipoprotein B levels.