-transparent.png){kind=logo}
1. Glucuronidation of clofibric acid, the pharmacologically active form of the hypolipidemic drug clofibrate was investigated in a human population, either in vitro with liver homogenates from biopsies, or after ingestion of the drug and determination of the urinary metabolite. No difference in the glucuronidation rate according to age of the patients was observed. Bilirubin but not clofibric acid glucuronidation was significantly higher in women (106% increase), when expressed per gram of tissue. 2. The excretion of clofibryl glucuronide in women who took oral contraceptives was significantly enhanced by 25%. 3. In female rats, treatment with the contraceptive agent norethindrone also stimulated by 48% the formation of clofibrylglucuronide in liver microsomes.
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
October 2011,
Die Pharmazie,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
July 1973,
Lancet (London, England),
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
November 1983,
Journal of chromatography,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
April 1981,
Journal of chromatography,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
October 2000,
The Journal of pharmacology and experimental therapeutics,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
December 1967,
Lancet (London, England),
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
November 1976,
Innere Medizin,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
August 1967,
Lancet (London, England),
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
January 1981,
Patologia polska,
H F Liu, and
J Magdalou, and
A Nicolas, and
C Lafaurie, and
G Siest
January 1974,
Advances in biochemical psychopharmacology,
