-transparent.png){kind=logo}
Changes in sodium-22 turnover and total body potassium (TBK) were studied during acute (within 2 weeks after clipping) and chronic (12-14 weeks after clipping) phases in two-kidney, one-clip (2k, 1c) hypertensive rabbits by using a whole body counter. Sodium-22 injected intravenously was eliminated more rapidly in hypertensive rabbits than in controls. The biological half-life (BHL) of sodium-22 was shorter in hypertensive rabbits during both acute (p less than 0.05) and chronic phases (p less than 0.001). A significant negative correlation was obtained between the BHL of sodium-22 and blood pressure (r = -0.588, p less than 0.05) in hypertensive rabbits. TBK decreased significantly at the chronic phase in hypertensive rabbits (p less than 0.05), while TBK showed no significant change in controls. Serum sodium and potassium did not change during the observation period. Increased plasma aldosterone concentration was observed during the acute phase in hypertensive rabbits. These results suggested that sodium retention was not a major factor in the acute and chronic phases of 2k, 1c hypertension in rabbits and that pressure natriuresis could explain, at least in part, the lack of sodium retention. Furthermore, there appears to be a derangement in the intracellular potassium metabolism which may be associated with the maintenance rather than the development of hypertension.
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
October 1985,
Kidney international,
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 1997,
Clinical and experimental hypertension (New York, N.Y. : 1993),
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
August 1992,
Journal of hypertension,
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 1980,
Hypertension (Dallas, Tex. : 1979),
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 2013,
Biomedical reports,
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 2001,
International urology and nephrology,
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
April 1997,
Hypertension (Dallas, Tex. : 1979),
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 1994,
Investigative urology (Berlin, Germany),
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
September 1982,
Clinical science (London, England : 1979),
S Seto, and
T Kaku, and
M Kuramochi, and
K Hashiba, and
S Okajima
January 1986,
Nephron,
