Genetic divergence between two sympatric species of the Lutzomyia longipalpis complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production. 2008

R M M A Lins, and N A Souza, and A A Peixoto
Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.

The sandfly Lutzomyia longipalpis s.l. is the main vector of American Visceral Leishmaniasis. L. longipalpis s.l. is a species complex but until recently the existence of cryptic sibling species among Brazilian populations was a controversial issue. A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila, was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil. The results revealed para as the first single locus DNA marker presenting fixed differences between the two species in this locality. In addition, two low frequency amino-acid changes in an otherwise very conserved region of the channel were observed, raising the possibility that it might be associated with incipient resistance in this vector. To the best of our knowledge, the present study represents the first population genetics analysis of insecticide resistance genes in this important leishmaniasis vector.

UI MeSH Term Description Entries
D007303 Insect Vectors Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host. Insect Vector,Vector, Insect,Vectors, Insect
D007305 Insecticide Resistance The development by insects of resistance to insecticides. Insecticide Resistances,Resistance, Insecticide,Resistances, Insecticide
D007896 Leishmaniasis A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL). Leishmania Infection,Infection, Leishmania,Infections, Leishmania,Leishmania Infections,Leishmaniases
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D011576 Psychodidae Small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms. Important disease-related genera are PHLEBOTOMUS, Lutzomyia, and Sergentomyia. Lutzomyia,Moth Flies,Phlebotominae,Psychodinae,Sandflies,Sergentomyia,Sand Flies,Flies, Moth,Flies, Sand,Fly, Moth,Fly, Sand,Lutzomyias,Moth Fly,Sand Fly,Sandfly,Sergentomyias
D003380 Courtship Activities designed to attract the attention or favors of another. Courtships
D005819 Genetic Markers A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event. Chromosome Markers,DNA Markers,Markers, DNA,Markers, Genetic,Genetic Marker,Marker, Genetic,Chromosome Marker,DNA Marker,Marker, Chromosome,Marker, DNA,Markers, Chromosome
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000819 Animal Communication Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior. Animal Communications,Communication, Animal,Communications, Animal
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species

Related Publications

R M M A Lins, and N A Souza, and A A Peixoto
September 2002, Molecular biology and evolution,
R M M A Lins, and N A Souza, and A A Peixoto
June 1993, The American journal of tropical medicine and hygiene,
R M M A Lins, and N A Souza, and A A Peixoto
January 2013, Memorias do Instituto Oswaldo Cruz,
R M M A Lins, and N A Souza, and A A Peixoto
September 2008, Medical and veterinary entomology,
R M M A Lins, and N A Souza, and A A Peixoto
May 2000, Journal of medical entomology,
R M M A Lins, and N A Souza, and A A Peixoto
August 2002, Insect molecular biology,
R M M A Lins, and N A Souza, and A A Peixoto
June 1997, The American naturalist,
R M M A Lins, and N A Souza, and A A Peixoto
June 2004, Journal of molecular evolution,
R M M A Lins, and N A Souza, and A A Peixoto
March 2008, Memorias do Instituto Oswaldo Cruz,
Copied contents to your clipboard!