Expressions of P2X2 and P2X3 receptors in rat nodose neurons after myocardial ischemia injury. 2009

Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China.

The role of ATP is as a functional neurotransmitter and local intercellular signaling molecule. The nodose neurons express both P2X(2) and P2X(3) subunits in their plasma membrane. This study wants to observe the expression of P2X(2) receptor and the expression relationship between P2X(2) and P2X(3) in nodose neurons after myocardial ischemic injury. The expressions of P2X(3) immunoreactivity, mRNA and protein were analyzed by immunohistochemistry, in situ hybridization and western blotting. P2X(2) and P2X(3) immunoreactivity, mRNA expression had been increased after myocardial ischemia in nodose neurons. Myocardial ischemia enhanced P2X(2) and P2X(3) protein level in nodose ganglia after myocardial ischemia. P2X(2) receptor in nodose neurons participated in the transmission of cardiac pain. The changes of P2X(2) and P2X(3) immunoreactivities, mRNA and protein that occurred following myocardial ischemic injury in the nodose ganglia showed that a correlation existed between P2X(2) and P2X(3) expression. It suggests that P2X(2) receptor subtype in company with P2X(3) receptor subtype plays the important role in cardiac vagal sensory nociceptors with a sensitivity to ATP.

UI MeSH Term Description Entries
D008297 Male Males
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D009479 Neuropeptides Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells. Neuropeptide
D009620 Nodose Ganglion The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve. Nodose Ganglia,Ganglia, Nodose,Ganglion, Nodose
D005260 Female Females
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000255 Adenosine Triphosphate An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D017202 Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). Heart Disease, Ischemic,Ischemia, Myocardial,Ischemic Heart Disease,Disease, Ischemic Heart,Diseases, Ischemic Heart,Heart Diseases, Ischemic,Ischemias, Myocardial,Ischemic Heart Diseases,Myocardial Ischemias

Related Publications

Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
January 2014, PloS one,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
January 2007, Neuroscience,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
July 1998, The Journal of physiology,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
December 2010, Autonomic neuroscience : basic & clinical,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
February 2002, The Journal of comparative neurology,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
September 2001, Neurochemical research,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
January 2007, Acta histochemica,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
June 2016, The Journal of biological chemistry,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
December 1984, Biulleten' eksperimental'noi biologii i meditsiny,
Yunxia Wang, and Guilin Li, and Kehua Yu, and Shangdong Liang, and Fan Wan, and Changshui Xu, and Yun Gao, and Shuangmei Liu, and Jiari Lin
August 1998, Neuroreport,
Copied contents to your clipboard!