Biomaterial Database

[Effect of calcitonin on articular cartilage of osteoarthritis]. 2008

Yinna Zhang, and Wenya Wang, and Liu Zhang

Department of Pathology, Affiliated Hospital, North China Coal Medical College, Tangshan Hebei 063000, PR China.

OBJECTIVE To review the effect of calcitonin on cartilage and subchondral bone of osteoarthritis. METHODS Recent literatures about the effect of calcitonin on osteoarthritis was reviewed. RESULTS Calcitonin could promote the synthesis of important cartilage matrix such as proteoglycans and collagen II, propelling the regeneration of cartilage and subchondral bone. CONCLUSIONS Calcitonin can protect articular cartilage through promoting the synthesis of cartilage and inhibiting its degradation.

UI	MeSH Term	Description	Entries
D010003	Osteoarthritis	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses
D002116	Calcitonin	A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.	Thyrocalcitonin,Calcitonin(1-32),Calcitrin,Ciba 47175-BA,Eel Calcitonin,Calcitonin, Eel,Ciba 47175 BA,Ciba 47175BA
D002358	Cartilage, Articular	A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.	Articular Cartilage,Articular Cartilages,Cartilages, Articular