BIOMAT Database Logo BIOMAT Database Logo

Iron deficiency and sleep disordered breathing in children--cause or effect? 2009

Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Department of Otorhinolaryngology-Head and Neck Surgery, Royal Free Hospital, London, UK. ryan.kerstein@gmail.com

OBJECTIVE Iron deficiency is associated with paediatric sleep disturbances; in particular, restless leg syndrome (RLS) and periodic limb movement disorder (PLMD). Correction of iron deficiency has been shown to improve sleep disordered breathing (SDB) in certain adult populations. We evaluated the iron status of children diagnosed with SDB undergoing adenotonsillectomy. METHODS Consecutive children undergoing adenotonsillectomy for SDB between January 2007 and January 2008 were analysed. Routine blood tests were performed including full blood count and iron studies. Children were grouped according to age; 0-2 years (group A), 2-6 years (group B) and above 6 years (group C). Results were compared to local normal values and published data regarding normal values for paediatric populations. RESULTS 94 children were included (60 male, 34 female). Mean age was 3.9 years (range 1.2-13.4 years). Iron deficiency was most marked in group A (n=8), with levels of ferritin (12.4), Mean Cell Haemoglobin (MCH) (25.0), iron saturation (16%, normal 20-40%) all below normal and Hb at the bottom of the normal range (11.0, normal 11-14.5). In group B (n=76), ferritin (19.4) and MCH (26.5) were again below normal but were higher than for group A. Average Hb for group B was 11.9. CONCLUSIONS The association between low iron and SDB in children has not previously been described. The results of this study highlighted low iron status in the children undergoing adenotonsillectomy for SDB. This was most severe in children under 6 years old. It is unclear whether low iron levels represent a cause or effect of SDB.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007501 Iron A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Iron-56,Iron 56
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004909 Erythrocyte Indices ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC). Erythrocyte Hemoglobin, Mean Cell,Erythrocyte Size Determination,Erythrocyte Volume, Mean Cell,Hemoglobin, Erythrocyte, Mean Cell,Mean Corpuscular Volume,Red Cell Indices,Erythrocyte Diameter,Erythrocyte Index,Erythrocyte Indexes,Erythrocyte Thickness,Mean Cell Hemoglobin Concentration,Mean Cell Volume,Mean Corpuscular Hemoglobin,Mean Corpuscular Hemoglobulin Concentration,Red Cell Distribution Width,Red Cell Index,Red Cell Indexes,Cell Volumes, Mean,Corpuscular Volumes, Mean,Determination, Erythrocyte Size,Determinations, Erythrocyte Size,Diameter, Erythrocyte,Diameters, Erythrocyte,Erythrocyte Diameters,Erythrocyte Size Determinations,Hemoglobin, Mean Corpuscular,Hemoglobins, Mean Corpuscular,Index, Erythrocyte,Index, Red Cell,Indexes, Erythrocyte,Indexes, Red Cell,Indices, Erythrocyte,Indices, Red Cell,Mean Cell Volumes,Mean Corpuscular Hemoglobins,Mean Corpuscular Volumes,Size Determination, Erythrocyte,Size Determinations, Erythrocyte,Thickness, Erythrocyte,Volume, Mean Cell,Volume, Mean Corpuscular,Volumes, Mean Cell,Volumes, Mean Corpuscular
D005260 Female Females
D005293 Ferritins Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types. Basic Isoferritin,Ferritin,Isoferritin,Isoferritin, Basic
D006452 Hemoglobinometry Measurement of hemoglobin concentration in blood. Hemoglobinometries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep-disordered breathing in children.
March 1994, The Mount Sinai journal of medicine, New York,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
[Sleep-disordered breathing in children].
February 2009, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep-disordered breathing in children.
October 2001, Dental clinics of North America,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep-disordered breathing in children.
January 2009, Chang Gung medical journal,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
[Sleep-disordered breathing in children].
September 2012, Nihon Jibiinkoka Gakkai kaiho,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep Disordered Breathing in Children.
October 2015, Indian journal of pediatrics,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep-disordered breathing in children.
August 1998, Annals of medicine,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep Disordered Breathing in Children.
July 2022, JAMA otolaryngology-- head & neck surgery,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep-disordered breathing in children.
June 2000, Current opinion in pediatrics,
Ryan Kerstein, and Paul Stimpson, and Helen Caulfield, and Gareth Ellis
Sleep disordered breathing in children.
February 2010, The Indian journal of medical research,
Copied contents to your clipboard!