BIOMAT Database Logo BIOMAT Database Logo

Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats. 2008

Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan 610041, China.

In this study, lycopene extracted from tomatoes was evaluated to treat PF induced by BLM in rats. Sixty Sprague-Dawley rats were randomly divided into 3 groups of 20 rats each for a normal control group (group C), BLM-treated group (group M), and lycopene + BLM-treated group (group L). The rats in groups M and L were subjected to intratracheal instillation of BLM to induce PF; group C served as a sham control (intratracheal instillation of normal saline). Lycopene diluted with olive oil was administered at a dose of 5 mg/kg body weight once a day in group L after BLM instillation, and groups C and M were treated with the same amounts of olive oil. The pathologic alterations of lung tissues, the concentrations of TNF-alpha, NO, malonyldialdehyde, the activities of superoxide dismutase in plasma, and the expression of TNF-alpha in lungs were assessed on day 3, 7, 14, and 28 after BLM instillation. The results showed that the lung coefficients in group L were reduced (day 14, P < .01) as well as the extents of alveolitis (day 7 and 14, P < .05) and PF (day 14 and 28, P < .05) compared with group M. The concentrations of TNF-alpha (day 7, 14, and 28, P < .001), NO (day 14, P < .05), and malonyldialdehyde (day 3, P < .01) in plasma as well as the expression of TNF-alpha in lungs decreased, whereas the plasma superoxide dismutase activities increased (day 28, P < .05) in group L compared with group M. Our study demonstrates that lycopene can partially reduce the extent of PF induced by BLM in rats. These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008315 Malondialdehyde The dialdehyde of malonic acid. Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D010938 Plant Oils Oils derived from plants or plant products. Oils, Plant,Oils, Vegetable,Plant Oil,Vegetable Oil,Vegetable Oils,Oil, Plant,Oil, Vegetable
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001761 Bleomycin A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. BLEO-cell,Blanoxan,Blenoxane,Bleolem,Bleomicina,Bleomycin A(2),Bleomycin A2,Bleomycin B(2),Bleomycin B2,Bleomycin Sulfate,Bleomycins,Bleomycinum Mack,Bléomycine Bellon,BLEO cell,BLEOcell,Bellon, Bléomycine,Mack, Bleomycinum,Sulfate, Bleomycin
D002338 Carotenoids The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons containing 4 terpene subunits. Carotenes,Carotenoid,Tetraterpene Derivatives,Tetraterpenes,Carotene,Derivatives, Tetraterpene

Related Publications

Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Emodin alleviates bleomycin-induced pulmonary fibrosis in rats.
November 2016, Toxicology letters,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats.
January 2015, Frontiers in pharmacology,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE.
January 2015, Journal of biological regulators and homeostatic agents,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Dihydroartemisinin alleviates oxidative stress in bleomycin-induced pulmonary fibrosis.
July 2018, Life sciences,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Inhaled B7 alleviates bleomycin-induced pulmonary fibrosis in mice.
November 2021, Bioorganic & medicinal chemistry,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms.
January 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Yiqi Huayu decoction alleviates bleomycin-induced pulmonary fibrosis in rats by inhibiting senescence.
January 2022, Frontiers in pharmacology,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
[Experimental pulmonary fibrosis induced by bleomycin].
June 1970, Igaku to seibutsugaku. Medicine and biology,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis.
September 2007, Medical molecular morphology,
Changhua Zhou, and Wei Han, and Ping Zhang, and Meiying Cai, and Dapeng Wei, and Chongjie Zhang
Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model.
December 2017, Inflammation,
Copied contents to your clipboard!