Canine inflammatory myopathy associated with Leishmania Infantum infection. 2009

Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy. paciello@unina.it

Inflammatory myopathy associated with several infectious diseases occurs in dogs including those caused by Toxoplasma gondii, Neospora caninum, Ehrlichia canis and Hepatozoon canis. However, muscle disease due to Leishmania infection has been poorly documented. The aim of this study was to examine the distribution and types of cellular infiltrates and expression of MHC class I and II in muscle biopsies obtained from 15 male beagle dogs from a breeder group with an established diagnosis of leishmaniasis. Myopathic features were characterized by necrosis, regeneration, fibrosis and infiltration of mononuclear inflammatory cells consisting of lymphocytes, plasma cells and histiocytes. The predominant leukocyte populations were CD3+, CD8+ and CD45RA+ with lesser numbers of CD4+ cells. Many muscle fibers had MHC class I and II positivity on the sarcolemma. There was a direct correlation between the severity of pathological changes, clinical signs, and the numbers of Leishmania amastigotes. Our studies provided evidence that: 1) Leishmania should be considered as a cause of IM in dogs; 2) Leishmania is not present within muscle fibers but in macrophages, and that 3) the muscle damage might be related to immunological alterations associated with Leishmania infection. Leishmania spp. should also be considered as a possible cause in the pathogenesis of human myositis.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007898 Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African. Black Fever,Kala-Azar,Fever, Black,Kala Azar,Visceral Leishmaniasis
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297 Male Males
D009220 Myositis Inflammation of a muscle or muscle tissue. Inflammatory Myopathy,Myositis, Focal,Myositis, Infectious,Idiopathic Inflammatory Myopathies,Idiopathic Inflammatory Myopathy,Idiopathic Inflammatory Myositis,Infectious Myositis,Inflammatory Muscle Diseases,Inflammatory Myopathies, Idiopathic,Inflammatory Myopathy, Idiopathic,Muscle Diseases, Inflammatory,Myopathies, Idiopathic Inflammatory,Myopathy, Inflammatory,Myositis, Proliferative,Focal Myositides,Focal Myositis,Infectious Myositides,Inflammatory Muscle Disease,Inflammatory Myopathies,Muscle Disease, Inflammatory,Myopathies, Inflammatory,Myopathy, Idiopathic Inflammatory,Myositides,Myositides, Focal,Myositides, Infectious,Myositides, Proliferative,Proliferative Myositides,Proliferative Myositis
D010950 Plasma Cells Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20) Plasmacytes,Cell, Plasma,Cells, Plasma,Plasma Cell,Plasmacyte
D002634 Chemotaxis, Leukocyte The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction. Leukotaxis,Leukocyte Chemotaxis
D004283 Dog Diseases Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used. Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006644 Histiocytes Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE). Histiocyte

Related Publications

Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
January 2000, Memorias do Instituto Oswaldo Cruz,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
August 2021, Parasitology research,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
February 2010, Clinical and vaccine immunology : CVI,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
July 2003, Acta tropica,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
September 2011, Parasitology research,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
January 2008, Journal of veterinary internal medicine,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
January 2016, Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
April 2021, Veterinary parasitology, regional studies and reports,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
January 2018, Frontiers in cellular and infection microbiology,
Orlando Paciello, and Gaetano Oliva, and Luigi Gradoni, and Laura Manna, and Valentina Foglia Manzillo, and Slawomir Wojcik, and Francesca Trapani, and Serenella Papparella
January 2015, Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria,
Copied contents to your clipboard!