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Bordetella pertussis (B.p.) induces blast transformation of human lymphocytes; whole killed B.p. are more efficient than extracts obtained by sonication. Similar responses were obtained with each of the four strains used in the Danish pertussis vaccine. B.p. with low amounts of Protective Antigen and Histamine-Sensitizing Factor also induced lymphocyte transformation, but were less toxic to the lymphocytes at high concentrations. The supernatants of B.p. cultures were purified with respect to Lymphocytosis Promoting Factor; evidence is presented that these purified fractions possess T-lymphocyte mitogenic activity. Lymphocytes from all normal humans were stimulated by B.p., including cells from cord blood. Cells from childbearing women, obtained immediately after delivery, showed a general depression of lymphocyte transformation including the response to B.p. Children with whooping cough had a lower lymphocyte response to B.p. than healthy children. A highly significant correlation was observed between the responses to B.p. and to E. coli in the adults and newborn examined. It is concluded that the major part of the lymphocyte transformation induced by B.p. is non-specific.
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Y Sato
May 1983,
The Journal of antimicrobial chemotherapy,
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August 2000,
Respiratory medicine,
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W Ramhoj, and
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Y Sato
August 1976,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
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G A Hansen, and
A C Wardlaw, and
Y Sato
April 1979,
Biulleten' eksperimental'noi biologii i meditsiny,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
P E Christensen, and
W Ramhoj, and
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A C Wardlaw, and
Y Sato
May 1982,
Biochemistry,
V Andersen, and
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P Baekgaard, and
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W Ramhoj, and
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A C Wardlaw, and
Y Sato
March 2003,
Iranian journal of allergy, asthma, and immunology,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
P E Christensen, and
W Ramhoj, and
G A Hansen, and
A C Wardlaw, and
Y Sato
July 1970,
Experimental cell research,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
P E Christensen, and
W Ramhoj, and
G A Hansen, and
A C Wardlaw, and
Y Sato
October 1977,
Tissue antigens,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
P E Christensen, and
W Ramhoj, and
G A Hansen, and
A C Wardlaw, and
Y Sato
March 1979,
American journal of obstetrics and gynecology,
V Andersen, and
J B Hertz, and
S F Sorensen, and
P Baekgaard, and
P E Christensen, and
W Ramhoj, and
G A Hansen, and
A C Wardlaw, and
Y Sato
January 1975,
Intervirology,
