Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. 2009

Steve Abman, and Alan Jobe, and Victor Chernick, and Carol Blaisdell, and Mario Castro, and Maria I Ramirez, and James E Gern, and Garry Cutting, and Greg Redding, and James S Hagood, and Jeffrey Whitsett, and Steve Abman, and J Usha Raj, and Robyn Barst, and Gregory J Kato, and David Gozal, and Gabriel G Haddad, and Nanduri R Prabhakar, and Estelle Gauda, and Fernando D Martinez, and Robert Tepper, and Robert E Wood, and Frank Accurso, and W Gerald Teague, and Jose Venegas, and F Sessions Cole, and Rosalind J Wright, and Dorothy Gail, and Aaron Hamvas, and Carolyn Kercsmar, and James Kiley, and Gail Weinmann, and
Washington University School of Medicine, Medicine and Pediatrics, St. Louis, Missouri.

The Division of Lung Diseases of the National Heart, Lung and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease (PVD); sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases, (2) injury, regeneration, and repair in the developing lung, (3) PVD in children, (4) development and adaptation of ventilatory responses to postnatal life, (5) nonatopic wheezing: aberrant large airway development or injury? (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases, and (7) predictive and personalized medicine for children.

UI MeSH Term Description Entries
D012140 Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM. Respiratory Diseases,Respiratory System Diseases,Disease, Respiratory System,Disease, Respiratory Tract,Respiratory System Disease,Respiratory Tract Disease
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014481 United States A country in NORTH AMERICA between CANADA and MEXICO.
D054555 National Heart, Lung, and Blood Institute (U.S.) Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative. NHLBI,National Heart, Lung, and Blood Institute
D035843 Biomedical Research Research that involves the application of the natural sciences, especially biology and physiology, to medicine. Medical Research,Experimental Medicine,Investigational Medicine,Investigative Medicine,Research, Biomedical,Research, Medical,Medicine, Experimental,Medicine, Investigational,Medicine, Investigative

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