Biomaterial Database

Arginine-vasotocin influence on aggressive behavior and dominance in rainbow trout. 2009

Tobias Backström, and Svante Winberg

Evolutionary Biology Centre, Comparative Physiology, Uppsala University, Norbyvägen 18A, SE-752 36 Uppsala, Sweden.

The mammalian neuropeptide arginine-vasopressin (AVP) and its non-mammalian homologue arginine-vasotocin (AVT) are involved in social behavior including aggression in vertebrates. Juvenile rainbow trout (Onchorhynchus mykiss) are highly territorial and we tested the effect of two different doses each of AVT and Manning compound, an AVP V(1A) receptor antagonist, on aggressive behavior and the outcome of staged fights for social dominance in size matched pairs. Each pair consisted of one fish receiving AVT or Manning compound through an intracerebroventricular (icv) injection and one fish receiving a similar icv injection of saline. In addition, plasma cortisol and brain serotonergic activity were monitored. Fish receiving AVT at a dose of 200 ng became subordinate whereas AVT at a dose of 20 ng had no effect on the outcome of fights for social dominance. Further, Manning compound had no effect on the outcome of fights for dominance but at a dose of 200 ng it had an effect on fight duration. Fish receiving 200 ng Manning compound and losing dyadic fights appeared to take longer to become subordinate. Neither AVT nor Manning compound had any effects on plasma cortisol levels or brainstem serotonergic activity. The apparent inhibiting effect of AVT on aggression could be centrally mediated.

UI	MeSH Term	Description	Entries
D007276	Injections, Intraventricular	Injections into the cerebral ventricles.	Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D004291	Dominance-Subordination	Relationship between individuals when one individual threatens or becomes aggressive and the other individual remains passive or attempts to escape.	Dominance Subordination,Dominance-Subordinations
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006727	Hormone Antagonists	Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.	Antagonists, Hormone
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000374	Aggression	Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.	Aggressions
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001127	Arginine Vasopressin	The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.	Argipressin,Vasopressin, Arginine,Arg-Vasopressin,Argipressin Tannate,Arg Vasopressin