[Prospective memory in normal aging and Alzheimer's disease]. 2008

Estelle Eusop-Roussel, and Anne-Marie Ergis
Laboratoire de psychopathologie et de neuropsychologie cliniques, Institut de psychologie, Université René Descartes Paris 5, Boulogne-Billancourt. eroussel@ugecamidf.fr

Remembering to implement intented activities such as remembering to take medications is referred to as prospective memory (PM). Studies on aging and PM show important variations in the magnitude of the effect of age. One explanation, derived from the multiprocess framework, proposes that age differences depend on retrieval processing. It is thought to be automatic for event-based PM tasks by contrast to self-initiated processing for time-based PM tasks. Older adults generally perform worse than younger ones in laboratory tasks. PM tasks show pronounced age-related deficits, particularly in tasks demanding high level of controlled strategies (e.g. in time-based tasks versus in event-based tasks or, in low salience cue condition versus high salience cue condition in event-based tasks). However, age differences in PM tasks settings differ substantially across studies: some of them show that older adults perform as well as younger ones in event-based PM tasks, especially in ecological ones. Developmental psychologists have investigated this topic, and suggested that several factors could potentially be responsible for the age-related differences observed in MP. These differences could be related to the characteristics of PM cues (e.g. the strength of the association between PM cues and intended actions), the complexity or demands of the ongoing task, or the involvement of planning processes, in other words, the involvement of executive functions. PM deficits are important in mild Alzheimer's disease, even more important than episodic memory or executive functions deficits. This article presents a critical review of cognitive and neuropsychological studies that examined whether these factors or other partly mediate the older adults deficits in prospective memory, which are more important than those observed in episodic memory. The variability of results between studies points to the concept complexity.

UI MeSH Term Description Entries
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia

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