-transparent.png){kind=logo}
Proton magnetic resonance spectroscopy (1H-MRS) was used to investigate the membranes of macrophages activated by gamma-interferon in vitro and by Listeria monocytogenes in vivo. We report the appearance with activation, of a high resolution spectrum indistinguishable from that found in activated T and B cells and embryonic and malignant cell types previously studied. We furthermore show that proliferation is not a prerequisite for the appearance of this activated spectrum. This supports the idea that membrane 'activation' in all cells, irrespective of origin, may be accompanied by similar architectural changes, and suggests that a common pathway exists for the activation of cell membranes of the immune system, possibly important in the acquisition of increased motility. The use of 1H-MRS as a non-invasive tool for analysis of activation is discussed.
N J King, and
M H Ward, and
K T Holmes
April 1963,
Science (New York, N.Y.),
N J King, and
M H Ward, and
K T Holmes
February 1978,
FEBS letters,
N J King, and
M H Ward, and
K T Holmes
December 1968,
Nature,
N J King, and
M H Ward, and
K T Holmes
March 2002,
Biochimica et biophysica acta,
N J King, and
M H Ward, and
K T Holmes
January 1986,
International journal of cancer,
N J King, and
M H Ward, and
K T Holmes
April 2010,
Magnetic resonance in medicine,
N J King, and
M H Ward, and
K T Holmes
March 1985,
Biochemistry,
N J King, and
M H Ward, and
K T Holmes
September 1978,
European journal of biochemistry,
N J King, and
M H Ward, and
K T Holmes
March 1970,
Nature,
N J King, and
M H Ward, and
K T Holmes
January 1977,
Annual review of biophysics and bioengineering,
