BIOMAT Database Logo BIOMAT Database Logo

Pendolmycin, a new tumor promoter of the teleocidin A class on skin of CD-1 mice. 1991

S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo.

Pendolmycin, isolated from Nocardiopsis, is a compound structurally similar to teleocidin A, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters. Pendolmycin has a C5 dimethyl allyl group attached to C-7 of (-)-indolactam-V, whereas teleocidin A has a C10 linalyl group attached to the molecule. The structure-activity relationships of a hydrophobic moiety attached to (-)-indolactam-V were studied in four compounds, (-)-indolactam-V, pendolmycin, teleocidin A and newly synthesized 7-(nerolidyl)-(-)-indolactam-V in tests on inhibition of the specific [3H]TPA binding to a particulate fraction of mouse skin, activation of protein kinase C and induction of both adhesion of HL-60 cells and ornithine decarboxylase in mouse skin. The potencies of the compounds for these activities increased mainly depending on the length of the hydrophobic group. Pendolmycin had a tumor-promoting activity on mouse skin initiated with a single application of 7,12-dimethyl-benz[a]anthracene, and its potency was just between those of (-)-indolactam-V and teleocidin A. The role of the hydrophobic moiety is discussed with particular emphasis on the results obtained with 7-(nerolidyl)-(-)-indolactam-V.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007769 Lactams Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams. Lactam,Lactim,Lactims
D008235 Lyngbya Toxins Toxins isolated from any species of the genus LYNGBYA or similar chemicals from other sources, including mollusks and micro-organisms. These have been found to be potent tumor promoters. They are biosynthesized from TRYPTOPHAN; VALINE; and METHIONINE nonribosomally (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT). Lyngbya Toxin,Lyngbyatoxin,Lyngbyatoxins,Toxin, Lyngbya
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D011493 Protein Kinase C An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. Calcium Phospholipid-Dependent Protein Kinase,Calcium-Activated Phospholipid-Dependent Kinase,PKC Serine-Threonine Kinase,Phospholipid-Sensitive Calcium-Dependent Protein Kinase,Protein Kinase M,Calcium Activated Phospholipid Dependent Kinase,Calcium Phospholipid Dependent Protein Kinase,PKC Serine Threonine Kinase,Phospholipid Sensitive Calcium Dependent Protein Kinase,Phospholipid-Dependent Kinase, Calcium-Activated,Serine-Threonine Kinase, PKC
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004789 Enzyme Activation Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme. Activation, Enzyme,Activations, Enzyme,Enzyme Activations
D005260 Female Females
D000470 Alkaloids Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Teleocidin: new naturally occurring tumor promoter.
January 1982, Carcinogenesis; a comprehensive survey,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.
June 1990, Cancer research,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Total syntheses of indolactam alkaloids (-)-indolactam V, (-)-pendolmycin, (-)-lyngbyatoxin A, and (-)-teleocidin A-2.
June 2014, Chemical science,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
The structures of additional teleocidin class tumor promoters.
November 1986, Chemical & pharmaceutical bulletin,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.
August 2007, Cancer letters,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Activation of human lymphocytes by tumor promoter teleocidin.
May 1981, Biochemical and biophysical research communications,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Des-O-methylolivoretin C is a new member of the teleocidin class of tumor promoters.
March 1986, Japanese journal of cancer research : Gann,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Teleocidin, a tumor promoter, is a potent platelet-aggregating agent.
September 1981, Biochemical and biophysical research communications,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin.
October 1984, Gan,
S Nishiwaki, and H Fujiki, and S Yoshizawa, and M Suganuma, and H Furuya-Suguri, and S Okabe, and M Nakayasu, and K Okabe, and H Muratake, and M Natsume
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin.
March 1993, Cancer research,
Copied contents to your clipboard!