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Allixin, a phytoalexin isolated from garlic, was examined for its effects on aflatoxin B1(AFB1)-induced mutagenesis using Salmonella typhimurium TA100 as the bacterial tester strain and rat liver S9 fraction as the metabolic activation system. The effects of allixin on the binding of [3H]AFB1 to calf thymus DNA and on the formation of metabolites of [3H]AFB1 were also determined. Allixin showed a dose-related inhibition of Histidine+ revertants induced by AFB1. Allixin at 75 micrograms/ml inhibited [3H]AFB1 binding to calf thymus DNA and reduced formation of AFB1-DNA adducts. In addition, allixin exhibited a concentration-dependent inhibition of the formation of organosoluble metabolites and the glutathione conjugates of [3H]AFB1. The data indicate that the effect of allixin on AFB1-induced mutagenesis and binding of metabolites to DNA may be mediated through an inhibition of microsomal P-450 enzymes. Allixin may thus be useful in the chemoprevention of cancer.
T Yamasaki, and
R W Teel, and
B H Lau
March 2002,
Chemical & pharmaceutical bulletin,
T Yamasaki, and
R W Teel, and
B H Lau
January 1991,
Nutrition and cancer,
T Yamasaki, and
R W Teel, and
B H Lau
January 1997,
Life sciences,
T Yamasaki, and
R W Teel, and
B H Lau
June 1992,
Mutation research,
T Yamasaki, and
R W Teel, and
B H Lau
November 1990,
Cancer letters,
T Yamasaki, and
R W Teel, and
B H Lau
July 1990,
Cancer letters,
T Yamasaki, and
R W Teel, and
B H Lau
April 1987,
Mutation research,
T Yamasaki, and
R W Teel, and
B H Lau
December 2001,
The American journal of gastroenterology,
T Yamasaki, and
R W Teel, and
B H Lau
March 1979,
Proceedings of the National Academy of Sciences of the United States of America,
T Yamasaki, and
R W Teel, and
B H Lau
March 1989,
Cancer research,
