[The effect of inhibitors of arachidonic acid metabolism on cholera toxin-induced experimental diarrhea]. 1991

E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin

UI MeSH Term Description Entries
D008297 Male Males
D009637 Masoprocol A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. Nordihydroguaiaretic Acid,(R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol,Actinex,Dihydronorguaiaretic Acid,Nordihydroguaiaretic Acid, (R*,S*)-Isomer,meso-Nordihydroguaiaretic Acid,Acid, meso-Nordihydroguaiaretic,meso Nordihydroguaiaretic Acid
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002772 Cholera Toxin An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. Cholera Toxin A,Cholera Toxin B,Cholera Toxin Protomer A,Cholera Toxin Protomer B,Cholera Toxin Subunit A,Cholera Toxin Subunit B,Choleragen,Choleragenoid,Cholera Enterotoxin CT,Cholera Exotoxin,Cholera Toxin A Subunit,Cholera Toxin B Subunit,Procholeragenoid,Enterotoxin CT, Cholera,Exotoxin, Cholera,Toxin A, Cholera,Toxin B, Cholera,Toxin, Cholera
D003967 Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight. Diarrheas
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000098 Acetophenones Derivatives of the simplest aromatic ketone acetophenone (of general formula C6H5C(O)CH3).
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000930 Antidiarrheals Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. Antidiarrheal,Antidiarrheal Agent,Antidiarrheal Drug,Antiperistaltic,Antiperistaltics,Antidiarrheal Agents,Antidiarrheal Drugs,Antiperistaltic Agents,Antiperistaltic Drugs,Agent, Antidiarrheal,Agents, Antidiarrheal,Agents, Antiperistaltic,Drug, Antidiarrheal,Drugs, Antidiarrheal,Drugs, Antiperistaltic

Related Publications

E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
February 1999, Infection and immunity,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
March 1991, Biochimica et biophysica acta,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
March 1990, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
January 2000, Annals of the New York Academy of Sciences,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
October 1987, Biulleten' eksperimental'noi biologii i meditsiny,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
July 1985, Metabolism: clinical and experimental,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
November 1988, Clinical genetics,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
May 1986, Digestive diseases and sciences,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
March 1988, Current eye research,
E I Astashkin, and I G Pautova, and E P Krupnova, and I S Nikolaeva, and V I Diachenko, and A F Kolomiets, and A V Fokin
July 1989, Investigative ophthalmology & visual science,
Copied contents to your clipboard!