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The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
January 1953,
Advances in carbohydrate chemistry,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
July 1960,
Japanese journal of microbiology,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
January 2001,
Eksperimental'naia i klinicheskaia farmakologiia,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
January 1953,
Advances in carbohydrate chemistry,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
January 1965,
Chemical & pharmaceutical bulletin,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
April 1972,
Kekkaku : [Tuberculosis],
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
January 1966,
Annales Academiae Scientiarum Fennicae. Ser. A.5, Medica,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
April 1961,
Japanese journal of microbiology,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
April 1965,
The Journal of organic chemistry,
M G Danilets, and
Iu P Bel'skiĭ, and
N F Bel'skaia, and
E S Trofimova, and
E G Uchasova, and
A A Ligacheva, and
V I Agafonov
February 1965,
Chemical & pharmaceutical bulletin,
