BIOMAT Database Logo BIOMAT Database Logo

Cross-resistance of human multidrug-resistant cells to mitomycin C. 1991

K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo.

Human multidrug-resistant cells, K562/ADM, KB-C-4, AdrRMCF-7 and CEM/VLB100 showed 21-, 7.5-, 105- and 3.4-fold cross-resistance to mitomycin C (MMC). The resistance to MMC in K562/ADM, KB-C-4, AdrRMCF-7, CEM/VLB100 cells was reversed by 6.6 microM verapamil. Accumulation of [3H]MMC in K562/ADM, AdrRMCF-7 and CEM/VLB100 cells also decreased by 37, 26 and 33%, as compared with their drug-sensitive counterparts. In KB-C-4 cells, accumulation of [3H]MMC decreased by 60%, and efflux rate of [3H]MMC was slightly increased as compared to their parental KB-3-1 cells. Verapamil at 6.6 microM increased accumulation of [3H]MMC in these multidrug-resistant sublines. K562/ADM10, K562/ADM50, K562/ADM100 and K562/ADM250 cells, which showed 17- to 230-fold resistance to Adriamycin, also showed 0.8- to 7.3-fold cross-resistance to MMC. In these cell lines, the extent of resistance to Adriamycin (ADM) that was consistent with expression levels of P-glycoprotein shown by immunoblotting was directly proportional to the extent of their resistance to MMC. Regression analysis indicated that relative resistance to Adriamycin was correlated with relative resistance to MMC (r = 0.98). These results indicate that MMC can be transported by P-glycoprotein overexpressed in multidrug-resistant cells.

UI MeSH Term Description Entries
D007951 Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites. Granulocytic Leukemia,Leukemia, Granulocytic,Leukemia, Myelocytic,Leukemia, Myelogenous,Myelocytic Leukemia,Myelogenous Leukemia,Myeloid Leukemia,Leukemia, Monocytic, Chronic,Monocytic Leukemia, Chronic,Chronic Monocytic Leukemia,Chronic Monocytic Leukemias,Granulocytic Leukemias,Leukemia, Chronic Monocytic,Leukemias, Chronic Monocytic,Leukemias, Granulocytic,Leukemias, Myelocytic,Leukemias, Myelogenous,Leukemias, Myeloid,Monocytic Leukemias, Chronic,Myelocytic Leukemias,Myelogenous Leukemias,Myeloid Leukemias
D008937 Mitomycins A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
D004317 Doxorubicin Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Adriamycin,Adriablastin,Adriablastine,Adriblastin,Adriblastina,Adriblastine,Adrimedac,DOXO-cell,Doxolem,Doxorubicin Hexal,Doxorubicin Hydrochloride,Doxorubicin NC,Doxorubicina Ferrer Farm,Doxorubicina Funk,Doxorubicina Tedec,Doxorubicine Baxter,Doxotec,Farmiblastina,Myocet,Onkodox,Ribodoxo,Rubex,Urokit Doxo-cell,DOXO cell,Hydrochloride, Doxorubicin,Urokit Doxo cell
D004351 Drug Resistance Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration. Resistance, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured
D014750 Vincristine An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) Leurocristine,Citomid,Farmistin,Oncovin,Oncovine,Onkocristin,Vincasar,Vincasar PFS,Vincristin Bristol,Vincristin medac,Vincristine Sulfate,Vincrisul,Vintec,cellcristin,PFS, Vincasar,Sulfate, Vincristine
D016685 Mitomycin An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis. Mitomycin C,Ametycine,Mitocin-C,Mitomycin-C,Mutamycin,NSC-26980,Mitocin C,MitocinC,NSC 26980,NSC26980

Related Publications

K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells.
June 1990, Biochemical and biophysical research communications,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line.
May 1995, International journal of cancer,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Biochemical mechanism of cross-resistance to paclitaxel in a mitomycin c-resistant human bladder cancer cell line.
March 2000, Cancer letters,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Mitomycin C induces multidrug resistance in glaucoma surgery.
February 2008, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Modulation of mitomycin C-induced multidrug resistance in vitro.
January 1991, Cancer chemotherapy and pharmacology,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Human multidrug resistant KB cells overexpress protein kinase C: involvement in drug resistance.
January 1989, Cancer communications,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro.
January 1990, Cancer chemotherapy and pharmacology,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance.
October 1987, Biochemical pharmacology,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Effects of BMY 25282, a mitomycin C analogue, in mitomycin C-resistant human colon cancer cells.
November 1985, Cancer research,
K Yusa, and W Sato, and A Yamazaki, and S Tsukahara, and T Tsuruo
Increased sensitivity of quinone resistant cells to mitomycin C.
June 1989, Cancer letters,
Copied contents to your clipboard!