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Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. 2005

Robert J Zawadzki, and Steven M Jones, and Scot S Olivier, and Mingtao Zhao, and Bradley A Bower, and Joseph A Izatt, and Stacey Choi, and Sophie Laut, and John S Werner
Department of Ophthalmology and Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, California 95817 rjzawadzki@ucdavis.edu.

We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (~4 μm) of retinal images, while maintaining the high axial resolution (~6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

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