-transparent.png){kind=logo}
Design and synthesis of vidarabine prodrugs as antiviral agents. 2009
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
TSRL Inc., 540 Avis Drive Suite A, Ann Arbor, MI 48108, USA. wshen@tsrlinc.com
5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.
Related Publications
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
February 2000,
The Journal of organic chemistry,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
February 2010,
Archives of pharmacal research,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
February 2023,
Viruses,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
December 2010,
Journal of agricultural and food chemistry,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
May 2008,
Bioorganic & medicinal chemistry,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
January 2013,
European journal of medicinal chemistry,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
November 1981,
Journal of pharmaceutical sciences,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
February 2019,
ChemMedChem,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
February 2020,
Bioorganic & medicinal chemistry letters,
Wei Shen, and
Jae-Seung Kim, and
Phillip E Kish, and
Jie Zhang, and
Stefanie Mitchell, and
Brian G Gentry, and
Julie M Breitenbach, and
John C Drach, and
John Hilfinger
May 2013,
Molecules (Basel, Switzerland),
