Short communication: analysis of immune function in lactating dairy cows fed diets varying in phosphorus content. 2009

I K Mullarky, and W A Wark, and M Dickenson, and S Martin, and C S Petersson-Wolfe, and K F Knowlton
Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA. mullarky@vt.edu

The aim of this study was to evaluate the effect of varying dietary P on bovine immune function. Nine first- or second-lactation Holstein cows were fed diets varying in P in a 3 x 3 Latin square design. Diets were formulated to contain either low (0.34%, no supplementary P), medium (0.43%), or high (0.52%) P. All 3 diets were formulated to meet or exceed current NRC requirements for P content. Between d 21 and 26 of each period, blood samples were collected and serum inorganic P concentration, lymphocyte proliferation, and neutrophil bactericidal activity were measured. Serum P increased with increasing dietary P intake and was greatest in the first lactation compared with subsequent lactations. There was a stage of lactation-dependent increase in lymphocyte proliferation after stimulation with concanavalin A, phytohemagglutinin, or pokeweed mitogen. However, dietary P did not alter lymphocyte proliferation or neutrophil bactericidal activity in vitro. In conclusion, decreasing dietary P to reduce manure P content and the risk of P losses from farms to surface water does not have an adverse effect on the innate or cell-mediated immune responses of lactating dairy cattle.

UI MeSH Term Description Entries
D007111 Immunity, Cellular Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role. Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D003612 Dairying Production, storage, and distribution of DAIRY PRODUCTS. Dairy Industry,Dairy Industries,Industries, Dairy,Industry, Dairy
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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