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A wide bore capillary gas chromatographic method was developed to determine mevalonolactone in capsule formulations. The method uses beta,beta-dimethyl-gamma-hydroxymethyl-gamma- butyrolactone as an internal standard and has been validated for its accuracy, precision and linearity. The method has been applied for stability testing of the capsule formulation. High-performance liquid chromatographic and gas chromatographic studies demonstrated cyclization of mevalonic acid (open-chain form) to mevalonolactone (cyclic form) under the described gas chromatography conditions. Mass spectrometric analysis indicated that mevalonolactone prepared in water or an organic solvent emerged from the gas chromatographic column as the intact cyclic lactone.
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
November 2005,
Se pu = Chinese journal of chromatography,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
January 1994,
Journal of analytical toxicology,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
May 1987,
Annals of clinical biochemistry,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
February 1979,
Clinica chimica acta; international journal of clinical chemistry,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
October 2001,
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
October 1975,
Clinica chimica acta; international journal of clinical chemistry,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
November 1984,
Journal of biochemical and biophysical methods,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
September 1984,
Bollettino della Societa italiana di biologia sperimentale,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
December 1984,
Journal of chromatography,
C J Lindemann, and
M M Singh, and
H G Ramjit, and
C Bell, and
D P Ip
January 1983,
Journal of analytical toxicology,
