Biomaterial Database

Diagnosis of brain death with technetium 99m hexamethylpropylene amine oxime. 1991

D C Costa, and I M Motteux, and A C McCready

Institute of Nuclear Medicine, UCMSM, Middlesex Hospital, London, UK.

We report on the utility of technetium 99m hexamethylpropylene amine oxime (99mTc-HMPAO) to diagnose brain death following cardiac surgery on a 49-year-old man with triple-vessel coronary artery disease. The imaging parameters and criteria to diagnose irreversible brain damage (brain death) with 99mTc-HMPAO are outlined. Brain imaging with this tracer seems to be more reliable than classic radionuclide angiography and has a potential value to confirm the diagnosis of brain death at an early stage. In addition, it may be used to evaluate the perfusion pattern to other vital organs with potential for transplantation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010091	Oximes	Compounds that contain the radical R2C	Aldoximes,Hydroxyimino Compounds,Ketoxime,Ketoximes,Oxime,Compounds, Hydroxyimino
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001926	Brain Death	A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)	Brain Dead,Coma Depasse,Irreversible Coma,Brain Deads,Coma, Irreversible,Death, Brain
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015609	Organotechnetium Compounds	Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.	Compounds, Organotechnetium
D019690	Technetium Tc 99m Exametazime	A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.	Tc-99m HMPAO,Technetium Tc 99m Hexamethylpropyleneamine Oxime,99m-Tc-HMPAO,99mTc-HMPAO,Ceretec,Tc-99m-Exametazime,Tc-99m-Hexamethylpropyleneamine Oxime,Technetium Tc 99m Hexamethylpropylene-amine Oxime,Tc 99m Exametazime,Tc 99m Hexamethylpropyleneamine Oxime,Technetium Tc 99m Hexamethylpropylene amine Oxime