-transparent.png){kind=logo}
We measured serum sex hormone-binding globulin (SHBG) using a radioimmunoassay developed by us, testosterone (T), estradiol (E2), free T and free E2 in 50 male patients with non-alcoholic liver cirrhosis (compensated: 30, decompensated; 20) and age-matched healthy male subjects, SHBG was significantly increased in patients with liver cirrhosis compared with healthy subjects. The high serum SHBG level in male compensated cirrhotic patients tended to decrease with progression to the decompensated state. Serum cholinesterase showed a positive correlation with SHBG in liver cirrhosis. Serum free T and the T/SHBG ratio decreased, while serum E2, free E2, and the E2/T and the free E2/free T ratios increased in liver cirrhosis, resulting in estrogen predominance and feminization of male patients. These changes were more marked in decompensated than compensated liver cirrhosis. An increased free E2/free T ratio was observed in patients with gynecomastia, palmar erythema or vascular spider. The T/SHBG ratio showed a positive correlation with serum free T, suggesting that it can be used as a free T index in liver cirrhosis. From these observations, it is suggested that serum SHBG plays an important role, by regulating the serum free T level in the occurrence of feminization in male patients with non-alcoholic liver cirrhosis.
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 2006,
Clinical chemistry and laboratory medicine,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 2022,
Frontiers in endocrinology,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
February 1980,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
November 2022,
Zhonghua nei ke za zhi,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
March 1989,
Acta endocrinologica,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 1997,
Journal of hepatology,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 1999,
Alcohol and alcoholism (Oxford, Oxfordshire),
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 1989,
Srpski arhiv za celokupno lekarstvo,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
January 1995,
Neuroscience and biobehavioral reviews,
Y Maruyama, and
Y Adachi, and
N Aoki, and
Y Suzuki, and
H Shinohara, and
T Yamamoto
May 2022,
Genes,
