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Parathyroid hormone (PTH) and catecholamines (CA) increased cAMP levels in isolated tubules of rat renal cortex. A rise in cAMP could be detected 10 sec after the addition of agonists, and it reached the peak in 30-60 sec and then decreased despite the presence of active agonists. Direct relationships exist between theophylline concentrations and cAMP levels in response to agonists. Three- to fivefold rises in cAMP levels were observed with a maximal dose of PTH compared with that of CA, and there was no additive effect. Both PTH and CA stimulated renal gluconeogenesis; when added together with each maximal dose, no additive effect was observed. These results suggest the important role of phosphodiesterase to control tubular cAMP in response to hormonal stimuli, and there is a tubule cell group responding to both PTH and CA.
K Kurokawa, and
G Lenchner, and
S G Massry
May 1981,
Prostaglandins,
K Kurokawa, and
G Lenchner, and
S G Massry
October 1973,
The American journal of physiology,
K Kurokawa, and
G Lenchner, and
S G Massry
March 1980,
Acta endocrinologica,
K Kurokawa, and
G Lenchner, and
S G Massry
July 1979,
Molecular and cellular endocrinology,
K Kurokawa, and
G Lenchner, and
S G Massry
July 1972,
Pediatrics,
K Kurokawa, and
G Lenchner, and
S G Massry
January 1978,
Biochemical pharmacology,
K Kurokawa, and
G Lenchner, and
S G Massry
November 1976,
Pflugers Archiv : European journal of physiology,
K Kurokawa, and
G Lenchner, and
S G Massry
April 1977,
Journal of cyclic nucleotide research,
K Kurokawa, and
G Lenchner, and
S G Massry
January 1978,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
K Kurokawa, and
G Lenchner, and
S G Massry
October 1975,
The Journal of endocrinology,
