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Abnormalities in VLDL and LDL apolipoproteins have been observed in the serum of an 11 year old girl with a type V hyperlipoproteinemia (VLDL + chylomicrons). This was shown with polyacrylamide gel electrophoresis and also with two dimensional immunoelectrophoresis. The LDL contain peptides which are not found in normal apo LDL. In the VLDL, heterogeneity of the lipopeptides is more marked that in normal VLDL, and there is an abnormal distribution of the apolipoproteins C or D.
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