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The Zn-alpha 2-glycoprotein (Zn-alpha 2-GP) is present at a high concentration in the seminal plasma and at significant levels in other human body fluids. Its precise localization, however, has remained unclear, as well as its physiological and pathological significance. The present study reports the immunohistochemical localization of this protein in normal adult human tissues. Localization of the reactive product to anti-human plasma Zn-alpha 2-GP antibody was demonstrated in the following cells: luminal and basal cells of the prostate gland, luminal epithelial cells of the acini and of some ducts of the mammary glands, luminal cells of the secretory portion of the eccrine and apocrine sweat glands, serous cells of the salivary, tracheal, and bronchial glands, acinar cells of the esophageal glands, exocrine acinar cells of the pancreas, hepatocytes of the liver, and epithelial cells of the proximal and distal tubules in the kidney. The present results suggest that Zn-alpha 2-GP exerts some unknown but fairly widespread exocrine function and may be produced in the various epithelial cells tested. Hepatocytes are also suggested to be a source of the protein in the blood plasma.
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
January 1980,
Laboratory investigation; a journal of technical methods and pathology,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
January 1993,
Pharmacology & toxicology,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
April 1961,
The Journal of biological chemistry,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
December 1990,
American journal of veterinary research,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
May 1990,
Biochimica et biophysica acta,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
March 1985,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
September 1976,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
May 1968,
The Journal of laboratory and clinical medicine,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
September 1991,
FEBS letters,
T Tada, and
I Ohkubo, and
M Niwa, and
M Sasaki, and
H Tateyama, and
T Eimoto
July 1990,
Calcified tissue international,
