Cardiac enzyme levels in myocardial dysfunction in newborns with perinatal asphyxia. 2008

P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

OBJECTIVE To study the usefulness of cardiac enzymes in evaluating myocardial damage in perinatal asphyxia. METHODS Thirty term babies with perinatal asphyxia and without any congenital malformations were selected as cases. They were compared with thirty healthy term babies without asphyxia. Myocardial dysfunction was evaluated using clinical, electrocardiography, echocardiography and cardiac enzymes i.e, troponin-T and CK-MB levels. RESULTS Among the 30 cases 23 had evidence of myocardial involvement while one baby in the control group had ECG evidence compatible with cardiac involvement. Cardiac enzymes were significantly increased in babies with perinatal asphyxia. The mean level of C-troponin-T among cases and controls were 0.22+/-0.28 and 0.003+/-0.018 while CK-MB levels were 121+/-77.4 IU/L and 28.8 +/- 20.2 IU/L respectively. C-troponin-T had higher sensitivity and specificity compared to CK-MB levels. Moreover, C troponin-T levels correlated well with severity and outcome in babies with perinatal asphyxia. CONCLUSIONS C-Tropopnin assay is useful in evaluating the severity of myocardial damage and outcome in perinatal asphyxia.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001238 Asphyxia Neonatorum Respiratory failure in the newborn. (Dorland, 27th ed)
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D052279 Creatine Kinase, MB Form An isoenzyme of creatine kinase found in the CARDIAC MUSCLE. Isoenzyme CPK-MB,MB Creatine Kinase,Myocardial Creatine Kinase,CPK-MB, Isoenzyme,Creatine Kinase, MB,Creatine Kinase, Myocardial,Isoenzyme CPK MB,Kinase, MB Creatine,Kinase, Myocardial Creatine
D020107 Troponin T A TROPONIN complex subunit that binds to TROPOMYOSIN. There are three troponin T subtypes: troponin T1, T2 and T3. Troponin T2 is cardiac-specific whereas troponin T2 and T3 are skeletal subtypes. Troponin T2 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin T2 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. Troponin T1,Troponin T2,Troponin T3,Troponin-T

Related Publications

P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
November 2019, Paediatrics and international child health,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
October 2018, Indian journal of pediatrics,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
August 2019, Indian journal of pediatrics,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
January 2004, Nutritional neuroscience,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
November 2013, Resuscitation,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
January 2001, Revista de neurologia,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
January 2016, Iranian journal of child neurology,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
October 2002, Neurology,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
February 2002, Neurology,
P S Rajakumar, and B Vishnu Bhat, and M G Sridhar, and J Balachander, and B C Konar, and P Narayanan, and G Chetan
April 1977, The Journal of pediatrics,
Copied contents to your clipboard!