BIOMAT Database Logo BIOMAT Database Logo

Does cigarette smoking exacerbate the effect of total cholesterol and high-density lipoprotein cholesterol on the risk of cardiovascular diseases? 2009

K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan. knaka@kanazawa-med.ac.jp

OBJECTIVE To explore whether an interaction between smoking and serum total cholesterol (TC) and/or decreased levels of serum high-density lipoprotein cholesterol (HDLC) exists for any major subtype of cardiovascular disease. METHODS An individual participant overview of 34 cohort studies. METHODS The Asia-Pacific region. METHODS People aged >or=20 years without a particular condition or risk factor. METHODS Hazard ratios (HRs) and 95% confidence intervals (CIs) for both TC and HDLC by smoking status were estimated using Cox proportional hazard models adjusted for age and systolic blood pressure and stratified by study and sex. RESULTS During follow-up (median 4.0 years), 3298 coronary heart disease (CHD) and 4318 stroke events were recorded. For CHD, the HR (95% CI) for an additional 1.06 mmol/l increment in TC was greater in current smokers than in non-smokers: 1.54 (1.43 to 1.66) versus 1.38 (1.30 to 1.47); p = 0.02. Similarly, the HR (95% CI) for an additional 0.40 mmol/l decrement in HDLC was greater in current smokers than in non-smokers: 1.67 (1.35 to 2.07) versus 1.28 (1.10 to 1.49); p = 0.04. The positive association of TC with ischaemic stroke, and the negative association of TC with haemorrhagic stroke, were broadly similar for current smokers and non-smokers. Similarly, the risks of both the subtypes of stroke remained broadly unchanged as HDLC decreased in both current smokers and non-smokers. CONCLUSIONS Smoking exacerbated the effects of both TC and HDLC on CHD, although no interaction between smoking and TC or HDLC existed for either of the subtypes of stroke.

UI MeSH Term Description Entries
D008076 Cholesterol, HDL Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol. High Density Lipoprotein Cholesterol,Cholesterol, HDL2,Cholesterol, HDL3,HDL Cholesterol,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,alpha-Lipoprotein Cholesterol,Cholesterol, alpha-Lipoprotein,alpha Lipoprotein Cholesterol
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010139 Pacific Islands The islands of the Pacific Ocean divided into MICRONESIA; MELANESIA; and POLYNESIA (including NEW ZEALAND). The collective name Oceania includes the aforenamed islands, adding AUSTRALIA; NEW ZEALAND; and the Malay Archipelago (INDONESIA). (Webster's New Geographical Dictionary, 1988, p910, 880) Pacific Island,Micronesia-Polynesia
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D004812 Epidemiologic Methods Research techniques that focus on study designs and data gathering methods in human and animal populations. Epidemiologic Method,Epidemiological Methods,Methods, Epidemiologic,Epidemiological Method,Method, Epidemiologic,Method, Epidemiological,Methods, Epidemiological
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001208 Asia The largest of the continents. It was known to the Romans more specifically as what we know today as Asia Minor. The name comes from at least two possible sources: from the Assyrian asu (to rise) or from the Sanskrit usa (dawn), both with reference to its being the land of the rising sun, i.e., eastern as opposed to Europe, to the west. (From Webster's New Geographical Dictionary, 1988, p82 & Room, Brewer's Dictionary of Names, 1992, p34)

Related Publications

K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Cigarette smoking, exercise and high density lipoprotein cholesterol.
July 1984, Atherosclerosis,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Effect of cigarette smoking on serum total cholesterol and high density lipoprotein cholesterol in normal subjects and coronary heart patients.
January 1989, Indian heart journal,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Effect of cigarette smoking on high density lipoprotein phospholipids.
January 1982, Biochemical and biophysical research communications,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio.
November 1988, Archives of internal medicine,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Addressing cardiovascular risk beyond low-density lipoprotein cholesterol: the high-density lipoprotein cholesterol story.
November 2004, Current cardiology reports,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Normalization of high density lipoprotein cholesterol following cessation from cigarette smoking.
January 1990, Advances in experimental medicine and biology,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Summaries for patients. Does low-density lipoprotein cholesterol influence the relationship between high-density lipoprotein cholesterol and cardiovascular risk in women?
December 2011, Annals of internal medicine,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Cigarette smoking, high-density lipoprotein cholesterol subfractions, and lecithin: cholesterol acyltransferase in young women.
October 2002, Metabolism: clinical and experimental,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
Total and high-density lipoprotein cholesterol and stroke risk.
July 2012, Stroke,
K Nakamura, and F Barzi, and R Huxley, and T-H Lam, and I Suh, and J Woo, and H C Kim, and V L Feigin, and D Gu, and M Woodward, and
The effect of total cholesterol/high-density lipoprotein cholesterol ratio on mortality risk in the general population.
January 2022, Frontiers in endocrinology,
Copied contents to your clipboard!