Biomaterial Database

[The effect of newer anthelmintics on Fasciola hepatica in experimentally infected rats]. 1976

J Corba

The reports deals with the results of testing seven new antihelminthics for Fasciola hepatica in the experimentally invaded Wistar rat. The greatest influence on juvenile flukes (2 and 4 weeks of age) was exerted by diamphenetid (Coriban) applied in a single dose of 100 mg kg-1. Hexachlorophene applied in the dose of 50 mg kg-1 showed the highest effect on sexually mature flukes. All the tested antihelminthics of the halogenated salicylanilide group were ineffective on juvenile stages and only slightly effective on mature F. hepatica flukes. It follows from the results that the effectiveness of some antifasciolics on laboratory animals need not always be in correlation with their effect in ruminants - hence it is necessary to verify the results obtained in laboratory animals and to check them on natural F. hepatica hosts.

UI	MeSH Term	Description	Entries
D009611	Nitroxinil	Proposed anthelmintic for fasciola and liver fluke infestations.	Nitroxynil
D009943	Organophosphorus Compounds	Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.	Organophosphorus Compound,Organopyrophosphorus Compound,Organopyrophosphorus Compounds,Compound, Organophosphorus,Compound, Organopyrophosphorus,Compounds, Organophosphorus,Compounds, Organopyrophosphorus
D010097	Oxyclozanide	Anthelmintic used in grazing animals for fasciola and cestode infestations.	Oxiclozanidum,Zanil
D011075	Polybrominated Biphenyls	Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.	Polybromobiphenyl Compounds,Biphenyls, Polybrominated,Compounds, Polybromobiphenyl
D011888	Rafoxanide	Veterinary anthelmintic for grazing animals; used to treat fluke, hookworm and other infestations.	Disalan,Flukanide,MK 990,Rafoxanid,Ranide
D003957	Diamfenetide	Anthelmintic. It has been shown to be useful in fasciola infections in sheep.	Diamphenethide,Acemidophen,Coriban,Di-(2-(4-acetamidophenoxy)ethyl) Ether
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005210	Fasciola hepatica	A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.	Liver Fluke,Fasciola hepaticas,Fluke, Liver,Flukes, Liver,Liver Flukes,hepatica, Fasciola
D005211	Fascioliasis	Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.	Fasciola Infection,Fasciola Infections,Fascioliases,Infection, Fasciola,Infections, Fasciola
D006582	Hexachlorophene	A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)	Hexachlorophane