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Construction of arginine-rich peptide displaying bionanocapsules. 2009
Takuya Shishido, and
Daisaku Yonezawa, and
Kiyokazu Iwata, and
Tsutomu Tanaka, and
Chiaki Ogino, and
Hideki Fukuda, and
Akihiko Kondo
Department of Molecular Science and Material Engineering, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.
Bionanocapsule (BNC) is a hollow nanoparticle composed of L-protein of the hepatitis B virus surface antigen. BNC can deliver genes or drugs into specific human hepatocytes, but delivery is limited to hepatocytes. In this study, we attempted to alter the specificity of BNCs by genetically introducing cell-penetrating peptides (CPPs), such as arginine-rich peptides, into BNCs. The CPP-fused BNC was efficiently internalized into various cell lines in a short period without significant cytotoxicity. These results show that CPP-BNC could be applied as an efficient carrier for gene and drug delivery.
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Journal of biochemistry,
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January 1998,
Biopolymers,
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Biochemical and biophysical research communications,
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Hideki Fukuda, and
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October 2017,
Proceedings of the National Academy of Sciences of the United States of America,
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February 2019,
Scientific reports,
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Akihiko Kondo
September 2010,
PloS one,
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Daisaku Yonezawa, and
Kiyokazu Iwata, and
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Chiaki Ogino, and
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December 2008,
Journal of molecular biology,
