BIOMAT Database Logo BIOMAT Database Logo

Effects of zinc on intestinal injury and some serum parameters in ethanol-administered rats. 2009

Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Turkey.

This study was designed to determine the morphological and biochemical effects of zinc sulfate and the role of metallothionein in ethanol-induced intestinal injury. Rats received zinc sulfate (100 mg/kg/d) for 3 consecutive d, 2 h prior to the administration of ethanol by gavage. Ethanol administration caused intestinal injury as determined by increased serum lactate dehydrogenase activity, urea, creatinine, uric acid, and sialic acid levels, intestinal lipid peroxidation level, decreased serum catalase activity, intestinal glutathione level, and metallothionein expression. Zinc sulfate pretreatment of the ethanol group caused a decrease in histological damage, serum lactate dehydrogenase activity, urea, creatinine, uric acid, sialic acid levels, and intestinal lipid peroxidation level, but increases in serum catalase activity, intestinal glutathione level, and metallothionein expression. The present study indicates that zinc sulfate has a protective effect against ethanol-induced intestinal injury. In addition, the protective effect of zinc on ethanol-induced intestinal injury might be mediated by metallothionein, as well as having antioxidative potential.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D007422 Intestines The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE. Intestine
D007770 L-Lactate Dehydrogenase A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist. Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008297 Male Males
D008668 Metallothionein A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals. Isometallothionein,Metallothionein A,Metallothionein B,Metallothionein I,Metallothionein II,Metallothionein IIA
D002374 Catalase An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA. Catalase A,Catalase T,Manganese Catalase,Mn Catalase
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats

Related Publications

Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of prenatal or postnatal ethanol consumption on zinc intestinal absorption and excretion in rats.
January 2007, Alcohol and alcoholism (Oxford, Oxfordshire),
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
The interactions of copper, lead and ethanol in rats: effects on some biochemical parameters of blood.
January 1989, Polish journal of pharmacology and pharmacy,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Influence of zinc-saccharide complexes on some haematological parameters in rats.
October 1997, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of zinc deficiency and supplementation on some hematologic parameters of rats performing acute swimming exercise.
January 2003, Acta physiologica Hungarica,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of ethanol administration on parameters of immunocompetency in rats.
May 1986, Journal of leukocyte biology,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of pregnanolone and dehydroepiandrosterone on ethanol intake in rats administered ethanol or saline during adolescence.
July 2009, Alcoholism, clinical and experimental research,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Zinc intestinal absorption in newborn rats at 21 day postpartum: effects of maternal ethanol consumption.
January 1998, Life sciences,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of folic acid and amino acids supplementation on zinc intestinal absorption in the progeny of ethanol-treated rats.
September 2000, Journal of physiology and biochemistry,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
The effects of peripherally administered monoaminergic drugs on ethanol diuresis in rats.
April 1986, The Journal of pharmacy and pharmacology,
Pelin Arda-Pirincci, and Bahar Bilgin-Sokmen, and Refiye Yanardag, and Sehnaz Bolkent
Effects of ethanol in vitro on some parameters of the immune response.
December 1989, Drug and alcohol dependence,
Copied contents to your clipboard!